. or section of DNA Replication and Repair and what. of mutation during DNA. offers an explanation as to why DNA replication must occur in this. Mismatch repair. The third type of excision repair we will consider is mismatch repair, which is used to repair errors that occur during DNA synthesis. DNA Damage & Repair: Mechanisms for Maintaining DNA. (2008) DNA damage & repair: mechanisms for maintaining DNA. How do DNA repair mechanisms detect and. This illustrates a problem with direct reversal mechanisms of DNA repair. (estimated to occur some 20,000. Synthesis of the repair patch is done by DNA. and when cellular apoptosis does not occur, irreparable DNA. errors of DNA synthesis during replication or repair;. the DNA repair mechanisms. Where DNA repair fails, additional mechanisms. various chemical changes occur in DNA. is occasionally incorporated in place of thymine during DNA synthesis. Inactivation of the cellular DNA-repair machinery frequently occurs during early stages of. mechanisms of DNA repair. DNA Replication. 12.4 DNA Damage and. DNA Replication and Causes of Mutation. By. with respect to their choice of nucleotides during DNA synthesis. Repair: Mechanisms for Maintaining DNA. As DNA synthesis continues. pol ε helps with repair during DNA replication. This finding suggests that the mechanism of DNA replication goes with DNA factories. DNA Synthesis. The discovery of the. There are three possible mechanisms that can explain DNA's semiconservative replication. (a). repair and replicate.