Novel enantioselective synthesis of + biotin
Deroose, Frederik, and Pierre De Clercq. 1993. “A Novel Enantioselective Synthesis of (+)-biotin.” Tetrahedron Letters 34 (27): 4365–4368. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine. Tetrahedron: Asymmetry 2003, 14 (23) , 3667-3672. DOI: 10.1016/j.tetasy.2003.08.034. Toshiaki SHIMIZU. A Novel and Practical Synthesis of (+)-Biotin via Fukuyama Coupling Reaction. Read ChemInform Abstract: A Novel Enantioselective Synthesis of (+)‐Biotin., ChemInform on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A conceptually simple enantioselective 14-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cycloaddition sequence involving (i) elimination of bromide 8 to the endocyclic thioenol ether 9, (ii) thermolysis of the ene carbamoyl azide 9 to the exocyclic thioenol ether 10.Both the synthesis of 8 and the final transformation of 10 into (+)-biotin. A conceptually attractive enantioselective 12-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cycloaddition sequence involving as key-steps (i) the macrothiolactonisation of acid 3 to Z-olefin 4, (ii) the thermolysis of the ene carbamoyl azide 5 in water with direct formation of a mixture of the benzylated derivatives of (+)-biotin 6a and 6b. Download Citation | On Aug 17, 2010, F. D. DEROOSE and others published ChemInform Abstract: Novel Enantioselective Syntheses of (+)-Biotin. | Find, read and cite all the research you need on. Download Citation | An efficient and enantioselective synthesis of d-biotin | An efficient and enantioselective synthesis of d-biotin 1 starting from cis-1,3-dibenzyl-2-imidazo-lidone-4,5. Deroose, Frederik, and Pierre De Clercq. 1995. “Novel Enantioselective Synthesis of (+)-biotin.” Journal of Organic Chemistry 60 (2): 321–330. Biotin: A Timeless Challenge for Total Synthesis. Chemical Reviews 1997, 97 (6) , 1755-1792. DOI: 10.1021/cr950073e. Stephen C. Bergmeier and, Dionne M. Stanchina. Synthesis of Vicinal Amino Alcohols via a Tandem Acylnitrene Aziridination−Aziridine Ring Opening. a novel enantioselective synthesis of (+)-biotin. By Frederik Deroose and Pierre De Clercq Topics: Science General.
