Vocabulary words for Quinolones. Includes studying games and tools such as flashcards. The 2- and 4-quinolones are a class of bicyclic molecules, organic chemical structures that are related to the heteroaromatic coal tar isolate quinoline, see image at. Quinolones. A drug may be. Quinolones are synthetic, bactericidal antibacterial agents with broad-spectrum activity. They inhibit the enzyme topoisomerase II. Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. J. Biol. Chem. 274: 35927-35932. Abstract / FREE Full Text. The quinolones are a family. First and second generation fluoroquinolones selectively inhibit the. Administration of quinolone antibiotics to a. inhibit bacterial DNA gyrase. Quinolones interfere with metabolism resulting in higher blood concentrations of theophylline and other xanthines. Effect. Quinolones: A Comprehensive Review. Quinolones rapidly inhibit DNA synthesis by promoting cleavage of bacterial DNA in the DNA-enzyme complexes of DNA gyrase and. fluoroquinolone [floor″o-kwin´o-lōn] any of a subgroup of quinolones that have a broader spectrum of activity than quinolones such as nalidixic acid. Quinolones and the Clinical Laboratory. How does resistance to quinolones develop? Quinolones inhibit. What organisms can be resistant to quinolones? Quinolones Inhibit DNA Religation Mediated by Staphylococcus aureus Topoisomerase IV CHANGES IN DRUG MECHANISM ACROSS EVOLUTIONARY BOUNDARIES*.